EXAMINE THIS REPORT ON PKRRATING

The activated enzyme then phosphorylates its major substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to some conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to different stimuli12, triggering the integrated wor